Use the phone, and select the "Extras" option, then choose the "Cheats" selection. Enter one of the following codes to activate the corresponding cheat function. Note: Achievements and auto save are disabled when cheats are activated. However, you are still allowed to manually save while cheats are enabled.
| Result | Code |
| Player Ability | |
| Money ($100,000) | cheese |
| Weapons | letsrock |
| Golden Gun (one-hit kills) | goldengun |
| Infinite sprint | runfast |
| No vehicle damage | vroom |
| Repair car | repaircar |
| Add respect | whatitmeanstome |
| Add police notoriety | pissoffpigs |
| No police notoriety | goodygoody |
| Add gang notoriety | lolz |
| No gang notoriety | oops |
| Vehicles | |
| Spawn Ambulance | giveambulance |
| Spawn Anchor | giveanchor |
| Spawn Attrazione | giveattrazione |
| Spawn Bootlegger | givebootlegger |
| Spawn Challenger | givechallenger |
| Spawn Commander | givecommander |
| Spawn Condor | givecondor |
| Spawn Eagle | giveeagle |
| Spawn Estrada | giveestrada |
| Spawn F69 Vtol | givevtol |
| Spawn Gatmobile | givegatmobile |
| Spawn Kaneda | givekaneda |
| Spawn Kenshin | givekenshin |
| Spawn Knoxville | giveknoxville |
| Spawn Krukov | givekrukov |
| Spawn Miami | givemiami |
| Spawn Municipal | givemunicipal |
| Spawn Nforcer | givenforcer |
| Spawn Peacemaker | givepeacemaker |
| Spawn Phoenix | givephoenix |
| Spawn Quasar | givequasar |
| Spawn Reaper | givereaper |
| Spawn Sandstorm | givesandstorm |
| Spawn Shark | giveshark |
| Spawn Specter | givespecter |
| Spawn Squasar | givesquasar |
| Spawn Status Quo | givestatusquo |
| Spawn Taxi | givetaxi |
| Spawn Titan | givetitan |
| Spawn Toad | givetoad |
| Spawn Tornado | givetornado |
| Spawn Vortex | givevortex |
| Spawn VTOL | givevtol |
| Spawn Vulture | givevulture |
| Spawn Widowmaker | givewidowmaker |
| Spawn Woodpecker | givewoodpecker |
| Weapons | |
| Spawn 45 Sheperd | givesheperd |
| Spawn Apocafists | giveapoca |
| Spawn AR 55 | givear55 |
| Spawn AS3 Ultimax | giveultimax |
| Spawn Baseball Bat | givebaseball |
| Spawn Chainsaw | givechainsaw |
| Spawn Cyber Blaster | givecybersmg |
| Spawn Cyber Buster | givecyber |
| Spawn D4TH Blossom | giveblossom |
| Spawn Electric Grenade | giveelectric |
| Spawn Flamethrower | giveflamethrower |
| Spawn Flash Bang | giveflashbang |
| Spawn GL G20 Grenade Launcher | givelauncher |
| Spawn Grave Digger | givedigger |
| Spawn Grenade | givegrenade |
| Spawn K-8 Krukov | givekrukov |
| Spawn KA-1 Kobra | givekobra |
| Spawn McManus 2015 | givesniper |
| Spawn Mini Gun | giveminigun |
| Spawn Molotov | givemolotov |
| Spawn Nocturne | givesword |
| Spawn RC Possesor | givercgun |
| Spawn Reaper Drone | givedrone |
| Spawn Riot Shield | giveshield |
| Spawn RPG Launcher | giverpg |
| Spawn S3X Hammer | givehammer |
| Spawn SA-3 Airstrike | giveairstrike |
| Spawn Satchel Charge | givesatchel |
| Spawn Shock Hammer | giverocket |
| Spawn Sonic Boom | givesonic |
| Spawn Stun Gun | givestungun |
| Spawn TEK Z-10 | givetek |
| Spawn The Penetrator | givedildo |
| Spawn Viper Laser Rifle | giveslm8 |
| Weather | |
| Sunny weather | clearskies |
| Cloudy weather | overcast |
| Rainy weather | lightrain |
| Very rainy weather | heavyrain |
| World | |
| Bloody Mess (everyone killed explodes into blood) | notrated |
| Heaven Bound (corpses rise into the air) | fryhole |
| Vehicle Smash | isquishyou |
| Drunk (drunk pedestrians) | dui |
| Mascots (mascot pedestrians) | mascot |
| Pimps and Hos (pimps and prostitutes pedestrians) | hohoho |
| Zombies (zombie pedestrians) | brains |
Enter the "whatitmeanstome" code, and activate it approximately ten to twenty times. This will result in you reaching Level 50, and gaining about $5 million. Then, enter the character abilities screen to buy all the fall, fire, bullet, explosion, and vehicle strike damage reduction options until it reaches "Never take damage". This will basically give you complete invincibility from all damage. Note: You may still die due to a minor glitch if you are in a normal vehicle and run over by a tank or if you crash with an aircraft.
Successfully complete the indicated task to unlock the corresponding vehicle:
- Wraith: Successfully complete the hard level of the Trailblazing Activity in Decker's territory.
- X2 Phantom motorcycle: Successfully complete Decker's version of the Trailblazing Activity (the other version that uses an ATV on fire is not required).
Successfully complete the indicated task to unlock the corresponding costume:
- Cops/SWAT: Successfully complete all Snatch activities for Kinzie.
- Deckers: Successfully complete the Assassination (Mission 37) from Kinzie that requires you to wear one.
- Hos: Successfully complete all Snatch activities for Zimos.
- Luchadores: Successfully complete Mission 43.
- Mascots: Successfully complete all of Professor Genki's S.E.R.C. activities.
- Morningstar: Successfully complete Mission 29.
- National Guard: Successfully complete all Tank Mayhem activities.
- Space Saints: Successfully complete Mission 47.
- Strippers: Successfully complete all Escort activities for Zimos.
- Wrestlers: Successfully complete Tiger Escort activities.
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